Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
For a few years, Namibia's dollar has been depreciating against many currencies, providing affordable opportunities for travel. The best-priced flights generally avoid South African and European school-holiday times, especially late December and January.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Rose McGowan accused producer Harvey Weinstein of rape this time last year, sparking an avalanche of allegations in the entertainment industry and beyond.
'12 Years A Slave' is shattering and anguishing, a singular anomaly in an entertainment medium. More than that, Steve McQueen's hugely ambitious chronicle of slavery in America is revelatory, a work of art that has been embraced by mainstream audiences. That's a testimony to the power of art (as expressed in John Ridley's script and performances by Chiwetel Ejiofor, Lupita Nyong'o and Michael Fassbender, among others), and heartening evidence of moviegoers' hunger for substance and meaning in the films they choose to see.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
In an emailed statement, FIFA said that during group stage matches, it sold a total of 143,364 of the cheapest tickets, which amounted to roughly 3,000 such tickets available per match.
Trends and targets in antiviral phototherapy
In the most significant change in methodology since this ranking was first published in 2005, the FT now collects information about alumni’s first jobs after graduation. These data are used in conjunction with information about their current jobs, three years later. This allows the FT to calculate their salary increase since graduation — a new ranking criterion — as well as their career progress (see methodology).
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
The Globes are unique in celebrating both film and television. Perhaps more than ever before, those lines were blurred Sunday, capping a year in which TV was much celebrated as the more dynamic storytelling medium. The beloved and now concluded 'Breaking Bad' earned some of the night's loudest cheers for its first Globe wins: best drama TV series and best actor in a drama for Bryan Cranston.
Novel biosensing methodologies for ultrasensitive detection of viruses
2015年英国《金融时报》全球高管工商管理硕士课程(Global Executive MBA，简称全球EMBA)排行榜由于两个原因而引人注目。不仅因为这是英国《金融时报》发布的第100个商学院排行榜，也是因为今年首次有一个主办方包含一所中国内地商学院的项目拔得头筹。
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
As foreign minister, Margot Wallstrom, who broke free from a violent relationship in her 20s, is challenging assumptions in a traditionally male sphere.
Diagnostic technologies for COVID-19: a review
The Meyerowitz Stories
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Beyoncé vs. Jennifer
It’s the time of the year for list making! This Youku video clip named the nine hottest lines on China’s web this year. The Yangtze Evening Post, an influential newspaper, is the original list compiler.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Adapted from an online novel Queen of No.11 Agent, the TV series is about the adventure of a female slave Chu Qiao and her romance with a prince Yan Xun.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
这部由塞巴斯蒂安.马拉比(Sebastian Mallaby)所著的《知者：格林斯潘传》(The Man Who Knew)，是这项奖金额为3万英镑的奖项的第12位获奖者。该奖项奖励的是年度“最令人瞩目和愉悦的”图书。
Another positive of the scheme is that it encourages professional flexibility, preparing the young for the career zigging and zagging that might be necessary in the modern world of work.
Here are some of the trends that emerge from this year’s BrandZ rankings:
Tesla has an order backlog of $226 million. At the production run rate of 1000 cars a week expected at the end of 2014, that translates to a 30-week backlog.
Influenza neuraminidase: A druggable target for natural products
adj. 受影响的，受感动的，受疾病侵袭的 adj. 做
Master of None
自该学校的国际管理学硕士(International Master in Management)项目首次被纳入榜单以来，该学校的排名在过去两年上升31个位置。
“I don’t think there are any companies that have survived big assaults from two of the biggest beasts in the hedge fund jungle,” says Ms Simpson of Calpers. “He is cool, calm and collected — the corporate exemplar of ‘Keep calm and carry on’.”
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
3. In Cannes, they speak English
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
INDOORS: The two-story house, of brick and stucco with a ceramic tile roof, was designed by Dorr & Dorr, completed in 1916 and renovated over the last 15 years. The style is part Prairie, part Arts and Crafts, employing clean lines, open space, elegant woodwork and colored glass. Renovations were done by Joseph Metzler of Sala Architects in Minneapolis.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Anxiety has been fanned by the build-up of corporate debt in emerging markets, which doubled between 2008 and 2014 and has been one of the fastest growing areas of the global bond market.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
TV Movie: “Sherlock: The Abominable Bride (Masterpiece)” (PBS)
But whether another hit product can emerge to fend off questions about Apple’s life after Jobs, Mr Cook learnt long ago to be patient and trust his instincts, just as he did when he ignored the doubters to join the then-struggling company in 1998.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
The price of U.S. benchmark West Texas Intermediate crude, which is traded on the New York Mercantile Exchange, has been kept lower by problems transporting the oil to markets. Those troubles have eased recently, but Sabine Schels, head of fundamental commodity research at Bank of America Merrill Lynch, doubts the problems will disappear.
Plenty of dark clouds loom over the U.S. job market -- particularly the potential double-punch of tax increases and spending cuts known as the fiscal cliff.[qh]
Inhibition of SARS coronavirus helicase by bismuth complexes
Due to the rapid growth of the online gaming sector, NetEase founder Ding Lei doubled his wealth to 96 billion yuan, surpassing Baidu Inc Chairman Robin Li and ranking third in the IT rich list.
China's manufacturing sector last month expanded at the slowest pace since March.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
In a bid to raise awareness of one of the world's most endangered species and the Chengdu Panda Base in China, the 108 performers were hard to miss as they entertained Londoners and children during school visits with conservationist and base ambassador Nigel Marven.
5、Poor e-mail communication
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Hope you enjoy the happiness of New Year and all the trimmings.祝你享尽新年佳节的快乐和新年的礼品。
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
PRICE PER SQUARE FOOT: $667
Confidence and a good elevator speech can take any pitch to the next level. The first marketing any company experiences comes from its founder. Spend time learning how to share your vision without coming across as “salesy.” Don’t be afraid to ask for the sale, but remember: the client is always the focus.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Shipments to China cratered by 14.4 per cent year-on-year to Rmb737.5bn in January. That’s from a 4 per cent drop in December, and versus expectations for a 1.8 per cent rise.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
We'll start our review with the South American nations, and who else could we begin with, but the hosts Brazil. Rewind 18 months and they looked like they'd be struggling, but the appointment of 'Big Phil' Scolari has been inspired, and he's brought a belief to the team that was previously missing. Last years 3:0 demolition of Spain in the Confederations Cup final shocked many experts, and all of a sudden the Brazilians have expectations on them. Whilst you can't argue with that scoreline, we still wonder if Brazil have the firepower to win such a long tournament. Neymar is expected to conjure up the magic, but they're relying on Fred to come up with the goals. No disrepect to Fred, but the last two Brazilian teams to win the World Cup, in 2002 and 1994, could count on the likes of Ronaldo and Romario to lead the front line, two genuine legends of the game.
“Policymakers around the world are cognisant of the impact the Fed decision will have and are worried, which makes us worried,” said Simon Lue-Fong, head of global emerging debt at Pictet Asset Management. “People are saying the decision is priced in but seeing as no one knows exactly what will happen how can that possibly be true.”
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
The report also shows that despite the rising pension insurance balance since 2012, the payable number of months fell to 17.7 months last year from 19.7 months in 2012.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
The country's improved performance has notched the 17th place in "innovation quality", an indicator that looks at the caliber of universities, number of scientific publications and international patent filings.
Ronaldo and Messi are the only football players in the top 20, which also features no women.
Guangdong has cemented its position as the country's largest provincial economy for the 28th consecutive year, with its gross domestic product (GDP) exceeding 7.9 trillion yuan in 2016.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Gunmen kidnapped 18 Turkish workers Wednesday in Iraq's capital.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Have a love filled New Year!
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
British business schools make up ground on their French counterparts in the revamped Financial Times ranking of masters in management degrees.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
"It's one of the strangest things that's ever happened to me," Beatty said backstage. "Thank God there were two of us up there," Dunaway responded.
A modular microarray imaging system for highly specific COVID-19 antibody testing
9. 米拉-库尼斯 1100万美元
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Despite the huge production, the focus was on the 40 gorgeous models who walked the runway.
Sina's Weibo service, for example, has long offered features that Twitter lacks, notably a commenting function that allows multiple users to add their own thoughts to a user's posts. Tencent's QQ instant messaging service, which has more than 700 million users, offers additional features such as skins to change the look of the client and serves as a portal for the company to advertise other products and services. Sina declined to comment.
6.You Spend Time Looking For Other Jobs
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
McGowan was born into the polygamous Children of God Cult and ran away from home in her teens.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
The system for ensuring responsibility is taken for poverty elimination will be effectively enforced, the strictest possible evaluations and assessments of poverty alleviation will be carried out, and stern measures will be taken to address deception, falsification, and the manipulation of numbers in poverty elimination work. We must see that the results of our poverty elimination earn the approval of our people and stand the test of time.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
He also posted a picture of himself looking at a racially diverse group of children.
For now, D'Aloisio isn't touching the money. 'I'm too young to appreciate the value of it,' he insists. 'I don't have a mortgage, I'm 17. To me, a hundred pounds is a lot. Take that as a benchmark.' Though he's not allowed to comment on Summly's sale price, when pressed he allows that he might one day like to deploy his newfound riches as an angel investor. No one around him seems to think there's a danger that the money will ruin him or that he'll be tempted to spend the rest of his life dissipating on a beach. 'He's pretty well grounded. You wouldn't believe how frugal he is,' says Diane. 'He's got a great engine,' says Lou. 'He won't stop at this.'
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Horowitz admitted that while doing so he has had to work carefully to preserve 007's characters and attitude as created by the spy novel’s first author Ian Fleming, who died in 1964.
A facile assay for rapid detection of COVID-19 antibodies
Lawrence’s 2016 earnings dropped 11.5 percent from her 2015 total of $52 million. Forbes will release its list of the world’s highest-paid actors on Thursday. Last year Robert Downey Jr. topped the list with an estimated $80 million.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
adj. 被识别的；经鉴定的；被认同者 v. 鉴定（id
Which showed month-on-month prices had fallen – albeit marginally – in Beijing, Tianjin, Shanghai, Shenzhen, Xiamen and Zhengzhou during the second half of the month.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
I know this takes time, but it'll ensure you really know your stuff. And that's why you're going to school. Right?
4.A Sex Video
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
在屏幕前对女主人公大喊“不要在深夜独自下楼”，不再是徒劳无用的了。在这款互动式惊悚游戏中，玩家可以控制游戏人物的行动。游戏的剧情由电影制片人拉里o法森顿和格拉哈姆o雷兹尼克与游戏开发商Supermassive Games精心打造。故事中，八位好友被困在遥远的山区度假村，还有一名不受限制的精神病人。游戏群星云集，其中包含《神盾局特工》（Agents of S.H.I.E.L.D）的演员布雷特o道顿，美剧《纳什维尔》（Nashville）的演员海顿o潘妮蒂尔和《极品飞车》（Need for Speed）的演员拉米o马雷克。玩家将控制各个角色探索这个恐怖的世界，试图在黎明到来时存活下来。没有人是安全的。在游戏中，每一个决定都会导致不同的结果。游戏剧本长达一千余页，拥有数百个不同结局等待玩家发掘。蝴蝶效应使得游戏不会有相同的剧情，而唯一不变的是，这款游戏十分惊悚。不要独自一人或是在深夜里尝试它。
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Haruhiko Kuroday, the Japanese central bank governor said: “I think we can be cautiously optimistic about the global outlook.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
A party of 108 pandas – performers dressed in costumes – descended on London streets today to promote the plight of the cuddly black and white endangered species.
Length-scale dependence of protein hydration-shell density
The other issue with tanking is Philly, Phoenix, and Brooklyn are all bad teams. It's going to be hard to outflank those outfits.
Financial advisors and asset allocators who had been hoping to see some benefit this year from tactical strategies were also not spared the punishment of a capricious market. Of the top three tactical strategies in the country (Mainstay Marketfield, Good Harbor U.S. Tactical Core, F-Squared Premium AlphaSector Index), two had nearly imploded with double-digit losses while the third found itself under SEC investigation for misleading the public about its historical returns. The other giant tactical manager, Schwab’s $9 billion Windhaven Diversified Growth product, looks to end 2014 with a return close to zero. So much for tactics.
'People go crazy and it gets overwhelming.'
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
迷你剧集/电影类最佳女演员：萨拉?保罗森(Sarah Paulson)，《美国罪案故事：公诉辛普森》(The People v. O. J. Simpson: American Crime Story)
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
位于芬兰赫尔辛基的开发商Remedy Entertainment通过之前的作品《英雄本色》（Max Payne）和《心灵杀手》（Alan Wake）模糊了好莱坞和游戏之间的界限。如今，这家工作室将次世代的图像技术与紧张气氛和电视剧剧本结合了起来。故事设置在Riverport大学城，玩家将控制杰克o乔伊斯和贝斯o怀尔德。这两人原本是普通人，但在一次导致时间裂缝的意外中，他们获得了操纵时间的超能力。在游戏过程中，时间体系会随时崩溃，导致环境中的时间暂停、断续、倒流和冻结。玩家在游戏中会与帝王联盟（Monarch Corporation）展开对抗，喜欢《英雄本色》中子弹时刻的玩家，可以在放大时间因素的枪战中寻找新的战略。除了虚拟的故事情节，游戏还采用了定制的实景真人叙事模式，根据玩家的不同选择将产生不同的后果。
Finance is one of top school Edhec’s core strengths, both in terms of teaching and research. The school in 2001 established the Edhec-Risk Institute to produce and distribute research on areas such as asset and risk management.
5. Constantly take action.
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